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KMID : 1007420150130030111
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Mood and Emotion
2015 Volume.13 No. 3 p.111 ~ p.119
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Effect of Early Life Stress on Response to Emotional Facial Stimuli in Patients with Major Depressive Disorder
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Song En-Jin
Choi Won-Jung
Oh Ji-Hee
Cha Saet-Byeol
Seok Jeong-Ho
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Abstract
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Objectives : The aim of this study is to investigate the effect of Early-life stress (ELS) including direct abuse(physical, emotional, sexual abuse) and indirect abuse (neglect) on response to emotional faces in the patients with major depressive disorder (MDD).
Methods : The participants were 21 patients with MDD and 23 healthy volunteers. Subjects were assessed concerning ELS, depressive symptom severity with self-report questionnaires. We developed an experimental task using emotional facial stimuli. The response characteristics of the MDD patients with ELS in four emotional conditions (positive, negative, neutral, combined) were compared with the patient without ELS and healthy control groups.
Results : There were significant effects of neglect in the neutral emotional task condition. MDD patients with neglect responded more negatively to neutral facial stimuli than the patient control and the healthy control groups. The MDD patient with direct abuse chose higher unpleasant response in neutral/pleasant condition than the patient control and the healthy control groups. In correlation analysis abuses and severity of depression correlated significantly with negatively biased response rate in neutral condition.
Conclusion : We found that ELS experiences might be a significant risk factor for pathological negativity bias in patients with MDD especially in the neutral and ambivalent emotional condition.
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KEYWORD
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Early-life stres, Major depressive disorder, Emotional reactivity, Negativity bias, Abuse, Neglect
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